Drug-drug interactions · ships on RapidAPI

The drop-in RxNav replacement.

The NLM RxNav Drug-Drug Interaction API shut down Jan 2, 2024. Mortar fills the gap: send a list of drug names, get pairwise interactions back in the same JSON shape — with RxNorm normalization built in.

Subscribe on RapidAPI OpenAPI spec
⚠️ Educational / informational only. Mortar is not clinical decision support, not comprehensive, and not a substitute for a pharmacist or physician. It never says a combination is "safe" or "unsafe." Every response includes a disclaimer field.

Why Mortar

Drop-in compatible

Responses mirror RxNav's findInteractionsFromList — point your old parser at Mortar and go.

RxNorm normalization

Generic names, brand names (Zocor → simvastatin), and even typos resolve to canonical RxCUIs automatically.

Commercial-use license

Built only from public, commercially-usable sources. No DrugBank, no NonCommercial data.

Optional AI explanations

Flip explain:true for a plain-language summary of each interaction, cached for instant repeat calls.

Quick start

curl -X POST "https://mortar-drug-interaction-api3.p.rapidapi.com/interactions" \
  -H "X-RapidAPI-Key: YOUR_RAPIDAPI_KEY" \
  -H "X-RapidAPI-Host: mortar-drug-interaction-api3.p.rapidapi.com" \
  -H "content-type: application/json" \
  -d '{ "drugs": ["warfarin", "aspirin", "simvastatin"] }'

Each interaction comes back grouped by source with severity and description, plus resolved / unresolved diagnostics. Calls go through the RapidAPI gateway.

Endpoints

MethodPathDescription
POST/interactionsPairwise interactions for a list of drugs.
GET/v1/manifestMachine-readable capability manifest (for AI agents).
GET/openapi.yamlOpenAPI 3.0 spec.
GET/healthLiveness + dataset readiness.

Plans

PlanPriceRequests / month
BasicFree2,500
Pro$12 / mo60,000
Ultra$59 / mo750,000
Mega$199 / mo7,000,000

Every plan includes RxNorm normalization, AI explanations, the commercial-use license, and the NLM-compatible response shape. Quotas and billing are managed by RapidAPI.